Frame nucleic acids are a type of artificially designed structural nucleic acids whose size, shape, and mechanical properties can be programmatically controlled. They provide structural support for molecular recognition and serve as basic tools for the diagnosis and treatment of major diseases. The importance of frame nucleic acids in the field of biotechnology can be seen from the mechanism of nucleic acids in the transmission of genetic information. Nucleic acid testing technology has played a key role in the prevention and control of infectious diseases such as COVID-19 and Ebola, and has shown broad prospects in molecular tracking during the replication process within cells. The continuous breakthroughs in related technologies are injecting strong impetus into the development of life sciences.In addition, the application of DNA origami technology has also made significant progress in the storage of life information. Frame nucleic acids have great potential in the localization of drug molecules and the development of diagnostic tools. The team has developed a new type of structure called "frame nucleic acids", which has provided strong support for the research and development of precise drugs.

Learning from nature is an eternal theme in natural science. In this report, researcher Jiang Lei was inspired by the efficient energy conversion mechanism of living organisms and delved deeply into the connection between biological ion channels and efficient energy conversion in living organisms. He revealed the crucial role of ion channels in biological information storage and output, as well as the high efficiency of enzyme channels in the synthesis of life substances. These discoveries not only enhance our understanding of the intrinsic working mechanism of living organisms, but also provide a theoretical basis for the development of new efficient energy conversion materials and low-energy consumption artificial intelligence technologies. They are of great significance for promoting the development of life science and technological innovation.

Stimuli-responsive theragnostic probes have emerged as powerful tools for integrated disease diagnosis and treatment. Among them, programable off–on–off systems represent a unique class of probes that undergo sequential activation and deactivation, enabling highly specific signal control and spatiotemporal precision. In this talk, we present the design and application of programmable theragnostic probes that are selectively activated by disease-associated biomarkers and subsequently deactivated upon therapeutic engagement or secondary stimuli. This reversible behaviour allows real-time monitoring of both pathological events and treatment progress. Building on this concept, we further developed a programmable singlet oxygen battery that enables deep-tissue disease treatment without relying on oxygen supply or light illumination, effectively overcoming the major limitations of traditional photodynamic therapy.

Functional dyes are widely used in optical recording, lighting display, biological imaging, medical diagnosis and treatment. It is still an important challenge to expand the luminescent properties and function regulation of fine chemical organic functional dyes, reduce the cost of material synthesis, and improve the economy of molecular material construction process. The construction strategy of "assembling-induced emission" is proposed to effectively regulate the fluorescence emission wavelength and room temperature phosphorescence efficiency of functional dyes and build functional and intelligent organic room temperature phosphorescence materials and product systems, which effectively expands the new functions and applications of traditional organic functional dye.

Metal clusters bridge atoms and nanoparticles as ideal models for studying structure–property relationships. However, ligand-protected coinage metal clusters (Au/Ag/Cu) often suffer from poor stability and weak emission, hindering precise synthesis of chiral, highly luminescent clusters. We developed site-specific modification and directed assembly to enhance stability and luminescence. We also established shell chirality control for efficient synthesis of enantiopure clusters, revealing shell-regulated electronic mechanisms that push luminescence efficiency toward the theoretical limit. Furthermore, we elucidated hierarchical chiral assembly mechanisms enabling exceptional circularly polarized luminescence (CPL), positioning these clusters among top CPL-active materials.