代谢生物学是整合生物化学、生理学、遗传学、医学等多领域的前沿交叉学科，旨在揭示生命活动的核心代谢机制、生理病理条件下的代谢变化规律以及生物体与环境的互作。随着基因组学、蛋白质组学、代谢组学等技术发展，该领域研究成果显著增长，已从传统生物学、医学拓展至化学、食品科学、环境科学及农林渔业、工程等多行业，展现出强大的多学科交叉特性和应用潜力。中国已成为该领域重要研究力量，并显示出巨大发展潜力。代谢生物学对解决人类健康、粮食安全、能源、环境等重大问题具有重要战略意义。 

当前，代谢生物学研究聚焦于多个关键领域。在"代谢与疾病"方面，重点研究代谢紊乱（如肥胖、糖尿病、心血管疾病）的分子机制，挖掘遗传易感基因与关键调控靶点，开发新诊疗策略。"代谢与新药研发"核心是加强"从0到1"的基础研究，发现新靶标，理解代谢紊乱在重大慢性疾病中的病理机制，推动创新药物研发。此外，代谢生物学还涵盖"代谢与主动健康"，探索生活方式干预代谢的分子机制；"人体共生微生物代谢"，解析微生物-宿主代谢网络作用；"代谢与农业"，改良作物代谢以提升产量和抗逆性；"代谢与合成生物学"，设计改造微生物高效生产有价值化合物；"代谢与生物材料"，优化生物材料的生物相容性；"代谢与生物质能源"及"代谢与碳中和"，利用代谢工程促进可再生能源生产和 CO₂生物固定；以及"新技术开发与代谢组学"，发展高灵敏度、高通量分析技术。 

为推动我国代谢生物学跨越式发展，建议国家层面加强顶层设计与资源整合，设立代谢相关研究重点专项，建立国家代谢生物学研究科技中心或全国重点实验室等国家级平台。重点专项通过多维度策略支持重大科学问题探索和关键技术突破，促进基础研究与产业应用衔接。国家级平台致力于搭建先进仪器共享平台，建立国家级代谢疾病资源库和特色天然产物库，开发人工智能系统解析代谢网络，培养高水平人才，攻克关键检测仪器和数据库等问题。通过这些举措，将提升我国代谢生物学研究的原始创新能力，推动相关产业健康发展，为国民健康和经济发展提供有力支撑。

Metabolic biology represents a cutting-edge interdisciplinary field that integrates biochemistry, physiology, genetics, medicine, and other domains, aimed at elucidating the core metabolic mechanisms underlying life activities, the patterns of metabolic changes under physiological and pathological conditions, and the interactions between organisms and their environment. With the advancement of genomics, proteomics, metabolomics, and related technologies, research achievements in this field have grown substantially, expanding from traditional biology and medicine to encompass chemistry, food science, environmental science, agriculture, forestry, fisheries, and engineering sectors, demonstrating remarkable interdisciplinary characteristics and application potential. China has emerged as one of the core research forces in this field and exhibits tremendous development potential. Research in this domain holds significant strategic importance for addressing major challenges in human health, food security, energy, and environmental sustainability.

Currently, metabolic biology research focuses on several key areas. In "Metabolism and Disease," emphasis is placed on elucidating the molecular mechanisms of metabolic disorders (such as obesity, diabetes, and cardiovascular diseases), identifying genetic susceptibility genes and key regulatory targets, and developing novel diagnostic and therapeutic strategies. The core of "Metabolism and Drug Development" lies in strengthening fundamental research "from zero to one," discovering new targets, understanding common pathological mechanisms of metabolic disorders in major chronic diseases, and advancing innovative drug development. Additionally, research encompasses "Metabolism and Proactive Health," exploring molecular mechanisms of lifestyle interventions; "Human Symbiotic Microbial Metabolism," analyzing microbehost metabolic network interactions; "Metabolism and Agriculture," improving crop metabolism to enhance yield and stress resistance; "Metabolism and Synthetic Biology," designing and engineering microorganisms for efficient production of valuable compounds; "Metabolism and Biomaterials," optimizing biocompatibility of biological materials; "Metabolism and Biomass Energy" as well as "Metabolism and Carbon Neutrality," utilizing metabolic engineering to promote renewable energy production and CO₂ biological fixation; and "New Technology Development and Metabolomics," advancing high-sensitivity, high-throughput analytical technologies.

To drive the strategic development of metabolic biology in China, it is recommended that the national level strengthen top-level design and resource integration, establish a key special program for metabolic biology, and construct a National Center for Metabolic Biology Science and Technology. The key special program shall support exploration of major scientific questions and breakthrough of critical technologies through multidimensional strategies, facilitating the integration of basic research with industrial applications. The National Science and Technology Center is committed to establishing advanced instrument-sharing platforms, building national-level metabolic disease resource banks and distinctive natural product libraries, developing artificial intelligence systems for metabolic network analysis, cultivating high-level talent, and addressing bottleneck issues in key detection instruments and databases. Through these initiatives, China's original innovation capacity in metabolic biology research will be enhanced, the healthy development of related industries will be promoted, and robust support will be provided for national health and economic development.