稳态（Homeostasis）是生命体维持内环境稳定的核心机制，其失衡是疾病发生的关键诱因。本报告系统阐述“稳态医学”（Homeostatic Medicine）的理论体系，提出以恢复机体稳态为目标的疾病防治新策略。重点聚焦口腔稳态对全身健康的影响，揭示唾液腺-口腔-胃肠-全身调控轴的作用；阐明硝酸盐经硝酸盐-亚硝酸盐-NO 途径及Sialin转运通道，通过调节NO稳态、线粒体功能与免疫微环境，维持心血管、代谢、神经等多器官稳态的分子机制。研究证实，膳食硝酸盐可改善放疗后唾液腺损伤、增强肿瘤化疗敏感性、缓解代谢紊乱。报告呼吁加强稳态医学的跨学科研究，推动基于硝酸盐-Sialin通路的新型药物研发，为慢性病防治提供创新思路。 

Homeostasis is the fundamental mechanism by which organisms maintain internal stability, and its disruption is a critical trigger of diseases. This report elaborates the theoretical framework of "Homeostatic Medicine", proposing novel strategies for disease prevention and treatment through restoring systemic homeostasis. We highlight the role of oral homeostasis in systemic health, particularly the salivary gland-oralgastrointestinal-systemic axis. Key findings demonstrate that dietary nitrate, via the nitrate-nitrite-NO pathway and the nitrate transporter Sialin, regulates NO homeostasis, mitochondrial function, and immune microenvironment, thereby sustaining the homeostasis of cardiovascular, metabolic, and neural systems. Dietary nitrate supplementation mitigates radiation-induced salivary gland dysfunction, enhances chemosensitivity in tumors, and ameliorates metabolic disorders. We advocate interdisciplinary collaboration to advance Homeostatic Medicine and develop novel therapeutics targeting the nitrate-Sialin pathway.