Photores Ponsive drug delivery systems can enhance the accumulation of therapeutic agents at targeted sites where light is applied, thereby maximizing therapeutic efficacy while minimizing side effects. Currently, this strategy faces challenges in clinical applications, such as limited light penetration depth in biological tissues. In this talk, I will present our research on the development of simple photoresponsive nanoassemblies for the treatment of cancer and eye diseases. Additionally, I will discuss the approaches we have developed to overcome the challenge of limited light penetration within the body. By exploring these advancements and solutions, we aim to further the potential of photoresponsive nanomedicine in treating a wide range of diseases through interdisciplinary collaborations.