Precision theranostics, as a key direction in the advancement of personalized medicine, is driving an integrated transformation in early disease detection, targeted molecular intervention, and dynamic therapeutic feedback. But so far, the realization of this vision remains highly challenging due to the intrinsic complexity of biological systems and the current lack of robust, precise molecular tools. The highly interdisciplinary chemical biology, bridging programmable chemistry and complex biology, offers unique advantages in addressing current challenges of new-generation medicines. By right, modern chemical biology is maturing into multifunctional toolboxes overflowing with customized molecular platforms, from disease-specific probes and intelligent imaging agents to function-oriented therapeutics. These tools drive entire continuum from deciphering disease mechanisms to conquering them, opening a new era of theranostics.

Alongside advances in the field of Chemical Biology and building on nearly two decades of research, we have established an expansive chemical-biology arsenal that uncovers previously hidden mechanisms of pathogenesis by specific response toward disease biomarkers. Leveraging these tools, the team has engineered multimodal imaging platforms for accurate diagnosis and explored molecular therapeutics for targeted disease intervention, while their chemical approach also boosted rapid drug screening and scaffold optimization. These cutting-edge tools effectively bridge the gap between fundamental research and clinical translation, injecting new momentum into the advancement of integrated and translatable precision medicine.