Ligand-coordinated noble metal nanoclusters, containing a couple to a few hundreds of atoms, bridge the gap between nanoparticles and molecular compounds. They show size-dependent fluorescence with a large Stokes shift, and are considered as rather environmentally benign. Compared to Au and Ag nanoclusters, elemental copper is significantly cheaper and is widely used in industries. Recently, thiol-stabilized Cu nanoclusters have attracted wide attention, and have been considered for several applications such as light emitting devices, chemical sensors, and biological imaging. Although the fluorescent properties of Cu nanoclusters are considered to be attractive, their photoluminescence quantum yields still need to be improved. This can be achieved by purposeful aggregation of these nanoclusters, either in solution or in different host matrices such as polymers, hydrogels and metal-organic frameworks, which allows us to make use of AIE effect as will be demonstrated in this talk.