The use of aggregation-induced emission luminogens (AIEgens) for imaging intracellular active molecules/biomolecules, and phototherapy has become an area of intense research. Recent contributions from our group for this topic will be presented; Supramolecular phthalocyanine assemblies-enhanced synergistic photodynamic and photothermal therapy guided by photoacoustic imaging, integrin-Targeted, Activatable nanophototherapeutics for immune modulation: enhancing photoimmunotherapy efficacy in prostate cancer through macrophage reprogramming, a hypoxia-triggered bioreduction of hydrophilic type I photosensitizer for switchable in vivo photoacoustic imaging and high-specificity cancer phototherapy.