We are entering the era of Digital-Chemistry whereby computer control can be used to monitor reactions, calculate reactivity and predict routes to targets but what next? In this talk I will explain how a programmable chemical computer or lchemputer5 can be used to do organic synthesis reactions making the process of chemical synthesis, safer, cheaper, more reliable, and freeing the chemist to focus on the more interesting aspects of synthesis, exploring for new reactivity and reactions 一 enabled by letting computers programme chemistry. But how is this possible? We had to devise a new architecture that would allow all chemistry to be done using a programming code in an universal way. This works because it is possible to make a hard link between the process of chemistry that is done in almost all labs in the world, using batch chemistry, and a programmable architecture that would allow us to make a universal programmable chemical synthesis engine.